NaP_SU2015_DCN

NaP_SU2015_DCN#

class braincell.channel.NaP_SU2015_DCN(size, g_max=Quantity(0.01, 'mS / cm^2'), name=None)#

Persistent sodium current of the deep cerebellar nuclei model.

Deep cerebellar nucleus (DCN) persistent sodium current, part of the model published as (Sudhakar et al., 2015) [2]:

\[\begin{split}\begin{aligned} m_\infty &= \frac{1}{1 + \exp((V + 70) / -4.1)} \\ \tau_m &= 50 / q \\ h_\infty &= \frac{1}{1 + \exp((V + 80) / 4)} \\ \tau_h &= \left[\frac{1750}{1 + \exp((V + 65)/-8)} + 250\right] / q \end{aligned}\end{split}\]

with \(V\) in mV and \(q\) = qdeltat; \(\tau_m\) is a bare constant with no voltage dependence. Gating is \(m^3 h\).

Parameters:

Notes

Ported from NaP_SU15_DCN.mod. NaP is one of only four mechanism names (with CaLVA, HCN and SK) that actually occur in the text of (Sudhakar et al., 2015) [2]; even so, the paper does not print these Boltzmann constants.

Kinetics originate in the GENESIS deep cerebellar nucleus model of Steuber et al. (2011) [1], translated to NEURON by Luthman et al. (2011), and reused by (Sudhakar et al., 2015) [2], which cites only the GENESIS model and not the NEURON translation.

The former NEURON TABLE tabulated minf, hinf and tauh (but not taum, which does not depend on voltage) over [-150, 100] mV and clamped outside that range; BrainCell evaluates the continuous formulas above at every call instead, so values outside [-150, 100] mV are expected to diverge from the original NEURON boundary-clamped output.

References

root_type#

alias of Sodium