NaF_SU2015_DCN

NaF_SU2015_DCN#

class braincell.channel.NaF_SU2015_DCN(size, g_max=Quantity(0.01, 'mS / cm^2'), name=None)#

Fast sodium current of the deep cerebellar nuclei model.

Deep cerebellar nucleus (DCN) fast sodium current, part of the model published as (Sudhakar et al., 2015) [2]:

\[\begin{split}\begin{aligned} m_\infty &= \frac{1}{1 + \exp((V + 45) / -7.3)} \\ \tau_m &= \left[\frac{5.83}{\exp((V - 6.4)/-9) + \exp((V + 97)/17)} + 0.025\right] / q \\ h_\infty &= \frac{1}{1 + \exp((V + 42) / 5.9)} \\ \tau_h &= \left[\frac{16.67}{\exp((V - 8.3)/-29) + \exp((V + 66)/9)} + 0.2\right] / q \end{aligned}\end{split}\]

with \(V\) in mV and \(q\) = qdeltat. Gating is \(m^3 h\).

Parameters:

Notes

Ported from NaF_SU15_DCN.mod. The mechanism name NaF does not appear anywhere in the text of (Sudhakar et al., 2015) [2]; this docstring says only that the mechanism is part of the published model, not that the paper names or describes it.

Kinetics originate in the GENESIS deep cerebellar nucleus model of Steuber et al. (2011) [1], translated to NEURON by Luthman et al. (2011), and reused by (Sudhakar et al., 2015) [2], which cites only the GENESIS model and not the NEURON translation.

The former NEURON TABLE tabulated minf, taum, hinf and tauh over [-150, 100] mV and clamped outside that range; BrainCell evaluates the continuous formulas above at every call instead, so values outside [-150, 100] mV are expected to diverge from the original NEURON boundary-clamped output.

References

root_type#

alias of Sodium